Cracking the retinal code

Jiang Lab

Department of Ophthalmology at Baylor College of Medicine

Publications of Dr. Jiang

  1. Jiang Z, Yue WWS, Chen L, Sheng Y, Yau K-W (2018) Cyclic-nucleotide- and HCN-channel-mediated phototransduction in intrinsically photosensitive retinal ganglion cells. Cell doi: 10.1016/j.cell.2018.08.055
  2. Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau K-W (2017) Synergistic signalings by light and acetylcholine in mouse iris sphincter muscle. Curr Biol.17: 30558-30567.
  3. Buhr ED, Yue WWS, Ren X, Jiang Z, Liao HW, Mei X, Vemaraju S, Nguyen MT, Reed RR, Lang RA, Yau K-W, Van Gelder RN (2015)Neuropsin (OPN5)mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proc. Natl. Acad. Sci. USA 112(42):13093-13098.
  4. Jiang Z, Yang J, Purpura LA, Liu Y, Ripps H, Shen W (2014) Glycinergic feedback enhances synaptic gain in the distal retina. Physiol592(Pt 7):1479-1492.
  5. Sun LO, Jiang Z, Rivlin-Etzion M, Hand R, Brady CM, Matsuoka RL, Yau K-W, Feller MB, Kolodkin AL (2013) On and off retinal circuit assembly by divergent molecular mechanisms. Science 342(6158):1241974.
  6. Matsuoka RL, Jiang Z, Samuels IS, Nguyen-Ba-Charvet KT, Sun LO, Peachey NS, Chedotal A, Yau K-W, Kolodkin AL (2012) Guidance-cue control of horizontal cell morphology, lamination, and synapse formation in the mammalian outer retina. Neurosci. 32(20):6859-6868.
  7. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau K-W (2011) Melanopsin signalling in mammalian iris and retina. Nature 479(7371):67-73.
  8. Jiang Z and Shen W (2010) Role of neurotransmitter receptors in mediating light-evoked responses in retinal interplexiform cells. Neurophysiol. 103(2):924-933.
  9. Shen W, Jiang Z, Li B (2008) Glycine input induces the synaptic facilitation in salamander rod photoreceptors. Biomed. Sci. 15(6):743-754.
  10. Jiang Z, Li B, Jursky F, Shen W (2007) Differential distribution of glycine transporters in Muller cells and neurons in amphibian retinas. Neurosci24(2):157-168.

About Dr. Jiang

During Dr. Jiang’s doctoral training, he focused on a type of glycinergic interneurons, called interplexiform cells (IPCs), which provide a glycine feedback to retinal circuitry. With electrophysiology and immunocytochemistry methods, we systematically characterized the pre- and post-synaptic neurons of IPCs.

Dr. Jiang did his Postdoctoral training in Dr. King-Wai Yau’s lab at Johns Hopkins University. His research at Johns Hopkins University is primarily focused on the functions and signaling mechanisms of intrinsically photosensitive retinal ganglion cells (ipRGCs), which play important roles in modulating cognitive functions. Combining behavioral assays, mouse genetics and electrophysiology, we found ipRGC subtypes utilize different phototransduction pathways, and serve different behavioral functions.In addition, he has made significant contribution to a collaborative research on retina development, in which we discovered new functions of guidance-cue molecules in retinal development.

Dr. Zheng Jiang’s CV